This Smart Guide identifies some of the current (2021) trends in the use of ICT, exploring good and bad practices, and examines the threats and challenges to sex workers’ safety, privacy, and well-being. It highlights the need for ICT developments that meet the highest security standards, are community-led and owned, that protect the health and other human rights of sex workers, and that do not replace essential face-to-face services for sex workers or undermine community empowerment at grassroots level. The Smart Guide draws on the expertise of sex workers and key informants and concludes with recommendations for different stakeholders.